GHK Peptide (GHK-Cu): What the Copper Tripeptide Is and How It Works

What is GHK-Cu?

GHK-Cu is a naturally occurring copper tripeptide consisting of glycine, histidine, and lysine bound to a copper(II) ion. First isolated from human plasma by Loren Pickart in 1973, it has since been identified in saliva, urine, and various tissue types. UK researchers can source GHK-Cu 100mg from Peptaro at above 99% HPLC purity with full third-party documentation.

Molecular Properties

GHK-Cu has the molecular formula C₁₄H₂₄CuN₆O₄ and a molecular weight of 403.9 g/mol. The copper(II) ion is integral to its biological activity, serving as a cofactor for lysyl oxidase and other metalloenzymes involved in collagen crosslinking and antioxidant defence. The compound is supplied as lyophilised powder with a characteristic blue tint due to the copper complex.

Gene Expression Modulation

Genomic research indicates that GHK-Cu influences the expression of over 4,000 human genes, approximately 6% of the human genome, including genes involved in DNA repair, proteasome function, oxidative stress response, anti-inflammatory pathways, and tissue remodelling. This broad genomic activity makes GHK-Cu a research tool of significant interest in studies of gene regulation and ageing biology.

Research Applications

GHK-Cu is studied in dermatological research models examining collagen synthesis, extracellular matrix remodelling, and skin barrier function; in hair follicle biology; in wound healing models; and in genomic research examining gene expression modulation. The copper ion serves as a cofactor for several metalloenzymes that contribute to its biological activity in research contexts.

Laboratory Handling and Storage

Store lyophilised vials at -20°C in a light-protected environment. Reconstitute with bacteriostatic water by injecting slowly down the inner wall and gently swirling, never shake. The reconstituted blue-tinged solution should be stored at 2-8°C in a light-protected container and used within 4 weeks. GHK-Cu is light sensitive, protect from prolonged UV and fluorescent light exposure throughout handling.

Sourcing GHK-Cu in the UK

Peptaro supplies research-grade GHK-Cu 100mg at above 99% HPLC purity, batch UKPL-377, tested by Marfleet Analytical Services, with same-day UK dispatch on orders before 3pm UK time and free tracked UK delivery on every order. For in-vitro laboratory research only, not for human consumption. Vial sizes and pricing are listed on the GHK-Cu UK buy page.