Ipamorelin 10mg

What is Ipamorelin ?

Ipamorelin is a synthetic pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2) with selective agonist activity at the ghrelin receptor. Research has examined its growth hormone secretagogue activity and its selectivity profile relative to other GHRP-class peptides. This 10mg presentation is the higher-mass research format of our 5mg vial.

Ipamorelin 10mg holds twice the lyophilised mass of our 5mg vial, in the same single-vial glass format. The compound is identical: the pentapeptide Aib-His-D-2-Nal-D-Phe-Lys-NH₂, molecular weight 711.85 g/mol, CAS 170851-70-4. It is a selective agonist at GHS-R1a, the ghrelin receptor. Raun and colleagues (Eur J Endocrinol, 1998) described it as the first selective growth hormone secretagogue. It came from a series of compounds that lack the central Ala-Trp dipeptide of GHRP-1.

Ipamorelin Research Applications

• Potency in vitro : in primary rat pituitary cells ipamorelin released GH with an EC50 of 1.3 nmol/l and an Emax of 85%. GHRP-6 gave 2.2 nmol/l and 100% (Raun et al., 1998).
• Selectivity : in swine it did not raise ACTH or cortisol even at more than 200 times the ED50 for GH release (Raun et al., Eur J Endocrinol, 1998). FSH, LH, PRL and TSH were unaffected.
• Bone growth : Johansen and colleagues (Growth Horm IGF Res, 1999) reported faster longitudinal bone growth in adult female rats, from 42 to as much as 52 µm/day. Total IGF-I did not change.
• Kinetics : Gobburu and colleagues (Pharm Res, 1999) built a pharmacokinetic-pharmacodynamic model of ipamorelin and the GH response.

Typical designs use ipamorelin as the selective agonist control in GHS-R1a binding or calcium-mobilisation assays in transfected cell lines. Others study pulsatile GH release or bone metabolism, or pair it with a GHRH-receptor agonist such as CJC-1295. The 10mg vial suits concentration-response matrices, long time-course work and analytical method development. Running the whole design on one batch keeps a single purity figure and certificate behind the dataset.

The 10mg Vial vs the 5mg Vial: Content, Cost and Working Life

Both vials hold the same peptide, so the choice is about logistics. At a fixed fill volume the 10mg vial reaches twice the concentration, so scale the water to the concentration your protocol needs. Cost per milligram falls with vial size, because vial, stopper, freeze-drying and testing costs are paid per vial. One batch and one certificate also cover twice as much work. Ipamorelin has no methionine, cysteine or tryptophan, so a longer in-use window carries less oxidation risk than for many peptides. What does grow is the number of stopper punctures and the working life of one stock, which aliquoting at reconstitution handles.

Research Overview

This page covers the 10mg presentation. The compound is the same synthetic pentapeptide supplied in the standard vial, sequence Aib-His-D-2-Nal-D-Phe-Lys-NH₂, molecular weight 711.85 g/mol, CAS 170851-70-4, a selective agonist at the ghrelin receptor GHS-R1a. Its characterisation by Raun and colleagues (Eur J Endocrinol, 1998) as the first selective growth hormone secretagogue, and the receptor context established by Howard and colleagues (Science, 1996) and Kojima and colleagues (Nature, 1999), are documented in full on the main Ipamorelin page. What is specific to the 10mg vial is handling and economics.

Ten milligrams is twice the content of the 5mg vial in the same single-vial glass format, so at a fixed fill volume the reconstituted stock is twice as concentrated. Fill volume must therefore be scaled to the target concentration rather than carried over from smaller-vial work, and the resulting concentration recorded against the batch. Unlike methionine-bearing peptides in the secretagogue class, ipamorelin carries no methionine, no cysteine and no tryptophan, and its D-amino acid and aminoisobutyric acid residues give the molecule marked stability in solution, so oxidative exposure is not the governing constraint on a larger vial. The constraints that do grow with vial size are microbial and mechanical: a vial holding twice the mass is typically accessed over a longer period and across more stopper penetrations, so sterility discipline and aliquoting into single-use volumes matter more here than on a 5mg vial.

The offsetting advantages are batch continuity under one certificate of analysis and a lower cost per milligram, since vial, stopper, lyophilisation and assay costs are incurred per vial rather than per milligram. Each vial contains 10mg of ipamorelin as white lyophilised powder, batch UKPL-9516, supplier-tested at 99.61% purity by HPLC, with the supplier certificate of analysis published on this page and independent third-party verification pending. Supplied strictly for in-vitro laboratory research use only.

Storage and Reconstitution

Store the sealed powder at -20°C, away from light and moisture. Reconstituted ipamorelin keeps for up to 4 weeks in the fridge at 2-8°C. On a 10mg vial the risks are repeated stopper punctures and freeze-thaw of one long-lived stock, not air exposure. Aliquot at reconstitution, freeze the aliquots, and thaw each one once.

Vials are sold on their own, without bacteriostatic water for mixing or other supplies.

How to reconstitute and handle

Let the vial and the bacteriostatic water reach room temperature, then swab both stoppers with alcohol. Add the water slowly down the inside wall of the vial, not onto the powder, and swirl gently until dissolved. Do not shake or vortex. The solution should be clear and colourless. Label the vial with the reconstitution date and the concentration.

• Scale the bacteriostatic water fill volume to your target concentration. A 10mg vial reaches twice the concentration of a 5mg vial at the same fill volume, so a volume carried across from smaller-vial work will not reproduce the same stock.
• The sequence contains no methionine, cysteine or tryptophan, and the D-amino acid and aminoisobutyric acid residues make ipamorelin comparatively resilient in solution, so no oxidation-specific handling is required. Sterility is the limiting factor.
• Aliquot into single-use volumes immediately after reconstitution and hold them at -20°C. A 10mg vial means a longer in-use window and more accumulated stopper penetrations on a single stock, and aliquoting isolates each withdrawal from that history.
• Introduce the diluent slowly down the inner glass wall, never onto the lyophilised cake, and swirl gently until fully dissolved. Allow the vial to reach room temperature before opening.
• Do not leave dilute solution standing at room temperature. Return aliquots to cold storage promptly after each withdrawal rather than working from a stock left out across a session, and avoid repeated freeze-thaw cycles.

For the full method, see the peptide reconstitution guide and the reconstitution calculator.

Research References

• Ipamorelin, the first selective growth hormone secretagogue (Eur J Endocrinol, 1998)
• Ipamorelin, a new growth-hormone-releasing peptide, induces longitudinal bone growth in rats (Growth Horm IGF Res, 1999)
• Pharmacokinetic-pharmacodynamic modeling of ipamorelin in human volunteers (Pharm Res, 1999)

Published research on Ipamorelin is indexed on PubMed. See our full UK buyer's guide for Ipamorelin 10mg, UK buyer's guide for Ipamorelin CoA and UK buyer's guide for Peptide Price per mg.