BPC-157 10mg

What is BPC-157 ?

BPC-157 is a synthetic 15-amino-acid peptide, a partial sequence of Body Protection Compound from human gastric juice. Published work on it is mostly cell and rodent research on angiogenesis, tendon fibroblasts and the gut lining. We sell it in 5mg and 10mg vials of white lyophilised powder.

BPC-157 (Body Protection Compound-157), also written BPC 157 or BPC157, is a pentadecapeptide with the sequence GEPPPGKPADDAGLV. Its molecular formula is C₆₂H₉₈N₁₆O₂₂, its molecular weight 1419.53 g/mol and its CAS number 137525-51-0.

Unlike most peptides of its length, it is stable in human gastric juice (Sikiric et al., Curr Med Chem, 2012). Its early clinical code was PL 14736.

BPC-157 Research Applications

• Angiogenesis : BPC-157 raised VEGFR2 expression and internalisation in human vascular endothelial cells and activated VEGFR2-Akt-eNOS signalling (Hsieh et al., J Mol Med, 2017).
• Tendon fibroblasts : in rat Achilles tendon cells it increased outgrowth, survival under oxidative stress and migration, with FAK and paxillin phosphorylation (Chang et al., J Appl Physiol, 2011).
• Growth hormone receptor : the same group found this receptor among the genes BPC-157 up-regulated most in these fibroblasts (Chang et al., Molecules, 2014).
• Gut models : the Sikiric group has studied it in animal models of colitis, intestinal anastomosis, short bowel syndrome and fistula (Curr Med Chem, 2012).

In the Hsieh study, BPC-157 increased vessel density in the chick chorioallantoic membrane assay and in endothelial tube formation. In rats with hind-limb ischaemia it sped the return of blood flow and raised vessel counts.

BPC-157 vs TB-500

The two share no sequence. BPC-157 has 15 residues (1419.53 g/mol); TB-500, as we sell it, is the 43-residue thymosin beta 4 chain (4963.4 g/mol). BPC-157 studies measure VEGFR2 and nitric oxide signalling in endothelial cells and focal adhesion signalling in tendon fibroblasts. Thymosin beta 4 studies measure G-actin binding and cell migration, mostly in cardiac and corneal models.

Research Overview

BPC-157, also written as BPC 157 or BPC157, is a synthetic pentadecapeptide with the sequence Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val (GEPPPGKPADDAGLV), molecular formula C₆₂H₉₈N₁₆O₂₂ and molecular weight 1419.53 g/mol. It corresponds to a partial sequence of Body Protection Compound, a protein originally characterised in human gastric juice, which is where the BPC abbreviation comes from. Its most distinctive physicochemical property is hydrolytic stability at low pH, unlike almost every peptide of comparable length, BPC-157 resists degradation in human gastric juice, a characteristic emphasised throughout the published work of Sikiric and colleagues (Curr Med Chem, 2012). The sequence is proline-rich, with three consecutive prolines followed by a fourth at position eight, and that conformationally constrained backbone is the usual structural explanation offered for the resistance. Mechanistic research has converged on the VEGF signalling axis. Hsieh and colleagues (J Mol Med, 2017) reported that BPC 157 upregulated VEGFR2 expression and promoted receptor internalisation and downstream signalling in human umbilical vein endothelial cells, with increased tube formation in vitro and greater vessel density in a rodent hindlimb ischaemia model. A parallel line of work by Chang and colleagues (J Appl Physiol, 2011) examined cultured rat Achilles tendon fibroblasts and reported increased outgrowth, survival and migration alongside elevated phosphorylation of focal adhesion kinase (FAK) and paxillin, the adaptor pair coupling integrin engagement to cytoskeletal reorganisation. Additional preclinical work describes interaction with the nitric oxide system and upregulation of growth hormone receptor in tendon fibroblasts. The honest position on human evidence is that it is thin. BPC 157 entered early-phase clinical development for inflammatory bowel disease as PL 14736 (Pliva, Croatia), and a 2025 pilot examined intravenous administration in a small cohort, but no adequately powered randomised controlled trial exists. Researchers sourcing BPC 157 in the UK should treat it as what the literature supports, an extensively characterised in vitro and animal-model tool compound, supplied strictly for research use only.

Storage and Reconstitution

Store sealed vials at -20°C, away from light and moisture. Stored this way, the lyophilised powder has a shelf life of up to 24 months. Reconstituted solutions keep for up to 4 weeks at 2-8°C. For longer storage, freeze single-use aliquots at -20°C and avoid repeated freeze-thaw cycles.

Vials are sold on their own, without bacteriostatic water for mixing or other supplies.

How to reconstitute and handle

Let the vial reach room temperature, then swab both stoppers with alcohol. Add the bacteriostatic water slowly down the inside wall of the vial, not onto the powder. Swirl gently until the powder has dissolved, without shaking or vortexing. The liquid should be a clear, colourless solution. Label the vial with the date.

• Avoid repeated freeze-thaw cycles. Aliquot reconstituted stock into single-use volumes for experimental reproducibility, and label each aliquot with the reconstitution date.

For the full method, see the peptide reconstitution guide and the reconstitution calculator.

Research References

• Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation (Hsieh et al., J Mol Med, 2017)
• BPC 157 promotes tendon healing via tendon outgrowth, cell survival and cell migration, FAK and paxillin phosphorylation (Chang et al., J Appl Physiol, 2011)
• Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts (Chang et al., Molecules, 2014)
• Focus on ulcerative colitis: stable gastric pentadecapeptide BPC 157 (Sikiric et al., Curr Med Chem, 2012)
• Regeneration or Risk? A Narrative Review of BPC-157 for Musculoskeletal Healing (McGuire et al., Curr Rev Musculoskelet Med, 2025)

Published research on BPC-157 is indexed on PubMed. See our full UK buyer's guide for BPC-157, UK buyer's guide for BPC-157 10mg and UK buyer's guide for Peptide Price per mg.